Download e-book for kindle: A Field Guide to Germs (Revised and Updated Edition) by Wayne Biddle


By Wayne Biddle

ISBN-10: 140003051X

ISBN-13: 9781400030514

From the ravages of the Ebola virus in Zaire to outbreaks of pneumonic plague in India and drug-resistant TB in big apple urban, contagious ailments are scuffling with again opposed to once-unconquerable sleek drugs. Public difficulty approximately infectious affliction is at the upward push as newspapers trumpet the arrivals of latest germs and the reemergence of previous ones.

In A box advisor to Germs, Pulitzer Prize-winning technology author Wayne Biddle brings readers nose to nose with approximately 100 of the best-known (in phrases of incidence, strength, ancient significance, or maybe literary curiosity) of the myriad pathogens that reside in and round the human inhabitants. in addition to actual descriptions of the organisms and the afflictions they reason, the writer presents folklore, philosophy, background, and such illustrations as 19th century drawings of plague-induced panic, microscopic images of HIV and Ebola, and wartime posters caution servicemen opposed to syphilis and gonorrhea.

From cholera to chlamydia, TB to HIV, bubonic plague to Lyme sickness, rabies to Congo-Crimean encephalitis, anthrax to Zika fever, and again to solid previous rhinitis (the universal cold), A box advisor to Germs is either a convenient reference paintings to raised comprehend today's headlines and a desirable examine the marvelous effect of micro-organisms on social and political history.

Winner of the yank clinical Writers Association's Walter C. Alvarez Honor Award.

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Extra info for A Field Guide to Germs (Revised and Updated Edition)

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Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000; 287:1497–1500. 135. Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci U S A 2000; 97:1263–1268. 136. Asahi M, Azuma T, Ito S, et al. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells.

141. Higashi H, Tsutsumi R, Fujita A, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A 2002; 99:14428–14433. 142. Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M. Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 2003; 278: 3664–3670. 143. Tebbutt NC, Giraud AS, Inglese M, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.

Pylori-colonized mucosa (Fig. 6) (40). TNF-α polymorphisms that increase TNF-α expression have now been associated with an increased risk of gastric cancer and its precursors (200). Smith and colleagues recently reported that polymorphisms within the IL-8 promoter that increase IL-8 expression also augment the risk for atrophic gastritis among H. pylori-infected subjects (201). Conversely, polymorphisms that reduce the production of anti-inflammatory cytokines may similarly increase the risk for gastric cancer and indeed El-Omar et al.

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A Field Guide to Germs (Revised and Updated Edition) by Wayne Biddle

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