Adenosine Receptors: Therapeutic Aspects for Inflammatory by Gyorgy Hasko, Bruce N. Cronstein, Csaba Szabo PDF

Immunology

By Gyorgy Hasko, Bruce N. Cronstein, Csaba Szabo

ISBN-10: 0849339995

ISBN-13: 9780849339998

After a century of analysis, numerous strains of facts now point out that the facility of adenosine to without delay keep an eye on inflammatory cells has an incredible impression at the features of the inflammatory and immune platforms. accordingly, many promising healing ways are starting to emerge that target the modulation of adenosine, together with the advance of compounds that intrude with the breakdown of adenosine, in addition to particular agonists and antagonists of varied adenosine subtypes. a few of these compounds have already entered medical trials. whereas details at the function of adenosine is transforming into swiftly, earlier it has remained scattered within the literature. Edited by means of 3 pioneering researchers within the box, Adenosine Receptors: healing points for Inflammatory and Immune illnesses provides the 1st unmarried quantity compilation of experiences on how adenosine, performing on its mobile receptors, regulates immune responses. The ebook is geared up to supply the reader with a basic review of adenosine receptors, delving into molecular biology, phone biology, and pharmacology. Separate chapters concentrate on the function of adenosine receptors in regulating the functionality of many of the phone varieties which are inquisitive about immune responses. extra chapters delineate the position of purinergic signaling within the pathophysiology of quite a few sickness states linked to an overzealous or inadequate immune reaction. those contain autoimmune ailments, bronchial asthma, atherosclerosis, ischemia-reperfusion damage, and melanoma. a lot of the method and findings documented during this textual content may perhaps bring about new healing modalities for pathologies akin to ischemia and reperfusion, middle sickness, wound therapeutic, tumors, ache, and numerous relevant worried process ailments together with Parkinson’s, Alzheimer’s, and epilepsy, in addition to temper and sleep issues. This source presents heritage and course for these researchers coming into the sphere of adenosine and inflammatory disorder, and gives a accomplished reference for skilled investigators.

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Selective agonists are in clinical trials for the treatment of rheumatoid arthritis and cancer. Selective antagonists are in preclinical testing for the treatment of glaucoma. In addition to the potential of directly acting orthosteric ligands, modulation of the ARs allosterically is a promising line of inquiry. The approach of genetic therapy with neoceptors could further achieve organ or tissue selectivity in the future. V. Joshi thanks Gilead Sciences, Foster City, CA, for financial support.

Karton, Y. , Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists, J. Med. , 39, 2293, 1996. 40. , Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype, J. Med. , 39, 4142, 1996. 41. Colotta, V. , 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies, J.

24. S. , N6-substituted D-4′-thioadenosine-5′-methyluronamides: potent and selective agonists at the human A3 adenosine receptor, J. Med. , 46, 3775, 2003. 25. A. , Methanocarba analogues of purine nucleosides as potent and selective AR agonists, J. Med. , 43, 2196, 2000. 26. Lee, K. , Ring-constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5′-uronamide and 2′-deoxy modifications, Bioorg. Med. Chem. , 11, 1333, 2001. 27. Tchilibon, S. , (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists, J.

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Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases by Gyorgy Hasko, Bruce N. Cronstein, Csaba Szabo


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